Minimally clinically significant. Monitor Closely (1)alfentanil and doxepin both increase sedation. Effect of interaction is not clear, use caution. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Use Caution/Monitor. Avoid or Use Alternate Drug. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. primidone, doxepin. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Use Caution/Monitor. Use Caution/Monitor. glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (1)doxepin, vortioxetine. QTc prolongation reported with higher than recommended doses of fostemsavir. Avoid or Use Alternate Drug. doxepin increases and fenfluramine decreases sedation. Mallinckrodt Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e17dc299-f52d-414d-ab6e-e809bd6f8acb. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Monitor Closely (1)benperidol and doxepin both increase sedation. liotrix increases effects of doxepin by Other (see comment). Monitor Closely (2)doxepin and methadone both increase QTc interval. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. For non-prescription products, read the label or package ingredients carefully. Accessed Aug. 19, 2019. Breckenridge Pharmaceutical, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4f31df66-7dc2-1f04-e054-00144ff88e88. Available for Android and iOS devices. Share cases and questions with Physicians on Medscape consult. butalbital, doxepin. Use Caution/Monitor. Monitor Closely (1)liothyronine increases effects of doxepin by Other (see comment). doxepin and nilotinib both increase QTc interval. Avoid or Use Alternate Drug. This content does not have an Arabic version. doxepin and levalbuterol both increase QTc interval. Other (see comment). Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. http://www.wolterskluwercdi.com/facts-comparisons-online/. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. ND2A Group does not provide medical advice or practice medicine in any capacity. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and amisulpride both increase QTc interval. Use Caution/Monitor. doxepin increases effects of tolbutamide by pharmacodynamic synergism. meclizine and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. May lower seizure threshold; keep bupropion dose as low as possible. doxepin and flecainide both increase QTc interval. Other (see comment). Use Caution/Monitor. Mechanism: unspecified interaction mechanism. atazanavir increases levels of doxepin by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. See additional information. doxepin and ribociclib both increase QTc interval. Use Caution/Monitor. 9th ed. Other (see comment). Monitor closely for signs of respiratory depression and sedation. Serious - Use Alternative (1)doxepin decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Increased antidepressant serum concentrations may occur. Monitor Closely (1)doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Citalopram may increase TCA levels. This report displays the potential drug interactions for the following 2 drugs: Applies to: Wellbutrin (bupropion) and doxepin. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and lapatinib both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Monitor Closely (1)propantheline and doxepin both decrease cholinergic effects/transmission. conjugated estrogens, doxepin. Monitor Closely (1)doxepin and gemifloxacin both increase QTc interval. Taking diphenhydramine (Benadryl) with doxepin could increase certain side effects, such as drowsiness, dizziness, confusion, and trouble concentrating. Contraindicated (1)lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: problems urinating (urinary retention), personal or family history of glaucoma (angle-closure type).This drug may make you drowsy. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Monitor Closely (1)methscopolamine and doxepin both decrease cholinergic effects/transmission. Risk of arrhythmias or hypotension. doxepin, buprenorphine subdermal implant. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. Comment: Inhibition of uptake by adrenergic neurons. dipipanone and doxepin both increase sedation. Avoid or Use Alternate Drug. ranolazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. doxepin and propafenone both increase QTc interval. Avoid or Use Alternate Drug. A double-blind controlled study comparing the effects of bupropion to doxepin in outpatients with primary depression was conducted to evaluate efficacy and safety differences between the two drugs. include protected health information. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, ephedrine. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Either increases toxicity of the other by sedation. amitriptyline and doxepin both increase QTc interval. Use Caution/Monitor.doxepin and levalbuterol both increase QTc interval. Modify Therapy/Monitor Closely. Use Caution/Monitor. atropine IV/IM and doxepin both decrease cholinergic effects/transmission. perphenazine and doxepin both increase QTc interval. Monitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. doxepin decreases effects of pitolisant by Other (see comment). Monitor Closely (1)doxepin and tacrolimus both increase QTc interval. Use Caution/Monitor.doxepin will increase the level or effect of ramelteon by unspecified interaction mechanism. Minor (1)doxepin increases effects of chlorpropamide by pharmacodynamic synergism. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. Use Caution/Monitor. desvenlafaxine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and pholcodine both increase sedation. doxepin and ramelteon both increase sedation. Modify Therapy/Monitor Closely. Either increases toxicity of the other by sedation. Minor/Significance Unknown. PRECAUTIONS: Before taking doxepin, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as amoxapine); or if you have any other allergies. Linezolid may increase serotonin as a result of MAO-A inhibition. Minor (1)doxepin increases effects of insulin glulisine by pharmacodynamic synergism. Monitor Closely (1)doxepin and leuprolide both increase QTc interval. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin, remifentanil. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Minor (1)zolpidem, doxepin. We comply with the HONcode standard for trustworthy health information. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Monitor Closely (1)midazolam and doxepin both increase sedation. Seasonal affective disorder treatment: Choosing a light box, Selective serotonin reuptake inhibitors (SSRIs), Serotonin and norepinephrine reuptake inhibitors (SNRIs), Staying active with hidradenitis suppurativa, Treating hidradenitis suppurativa: Explore your options, Treating hidradenitis suppurativa with antibiotics and hormones. Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days, Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose, 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day, Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime, Hepatic impairment: Use lower dose and adjust gradually for depression; initiate Silenor at 3 mg daily for insomnia, Starting dose: 3 mg PO within 30 minutes before bedtime, May increase to 6 mg PO HS if clinically indicated, Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS, May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated, Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension (Beers criteria), Consider alternatives; if must use, initiate with lower initial dose, May cause confusion and oversedation in elderly. Use Caution/Monitor. Use Caution/Monitor. Is It Safe? Other (see comment). doxepin and lofexidine both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. government site. fluphenazine and doxepin both increase sedation. chlorpromazine and doxepin both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. doxepin and ponesimod both increase QTc interval. doxepin increases and dexfenfluramine decreases sedation. doxepin, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. abiraterone increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases effects of repaglinide by pharmacodynamic synergism. opium tincture and doxepin both increase sedation. Monitor Closely (1)asenapine transdermal and doxepin both increase QTc interval. efavirenz and doxepin both increase QTc interval. doxepin and droperidol both increase QTc interval. duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, levalbuterol. Other (see comment). Profound sedation, respiratory depression, coma, and death may result if coadministered. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)ondansetron, doxepin. Ask your doctor when to start or stop taking this medication.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Cyclic antidepressants aren't considered addictive. escitalopram and doxepin both increase serotonin levels. Minor/Significance Unknown. Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (2)doxepin and tapentadol both increase serotonin levels. Use Caution/Monitor. Avoid or Use Alternate Drug. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Avoid or Use Alternate Drug. doxepin and protriptyline both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and yohimbine decreases sedation. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. doxepin increases effects of insulin aspart by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. doxepin increases and arformoterol decreases sedation. Mechanism: unspecified interaction mechanism. Monitor Closely (1)neostigmine increases and doxepin decreases cholinergic effects/transmission. Minor (1)mestranol, doxepin. Monitor Closely (2)doxepin and dexfenfluramine both increase serotonin levels. Monitor Closely (1)doxepin increases and pirbuterol decreases sedation. Tricyclic antidepressants. Use Caution/Monitor. Bupropion: overview and prescribing guidelines in depression. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.Minor (2)doxepin, trifluoperazine. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. doxepin increases and fenfluramine decreases sedation. Other (see comment). Additive anticholinergic effects. Use Caution/Monitor.desipramine and doxepin both increase sedation. Other (see comment). All rights reserved. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and haloperidol both increase QTc interval. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval. Monitor Closely (1)gabapentin, doxepin. Effect of interaction is not clear, use caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Informational purposes only. Effect of interaction is not clear, use caution. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. trifluoperazine and doxepin both increase QTc interval. Use Caution/Monitor. information highlighted below and resubmit the form. Use Caution/Monitor. information submitted for this request. Avoid or Use Alternate Drug. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? doxepin and daridorexant both increase sedation. Monitor Closely (1)doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. It may help you stay asleep longer and reduce the number of times you awaken during the night. Monitor Closely (1)trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. Other (see comment). selegiline transdermal and doxepin both increase serotonin levels. Other (see comment). Avoid or Use Alternate Drug. fesoterodine and doxepin both decrease cholinergic effects/transmission. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. Monitor Closely (2)doxepin, lisdexamfetamine. Minor/Significance Unknown. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. If concomitant use is required it's recommended that toremifene be interrupted. unspecified interaction mechanism. Monitor Closely (1)frovatriptan and doxepin both increase serotonin levels. ethinylestradiol, doxepin. There is 1 alcohol/food interaction with doxepin. Accord Healthcare Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd. Monitor Closely (1)doxepin and siponimod both increase QTc interval. thioridazine and doxepin both increase QTc interval. Monitor Closely (2)prochlorperazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and ranolazine both increase QTc interval. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. doxepin and desvenlafaxine both increase serotonin levels. Use Caution/Monitor. doxepin increases and benzphetamine decreases sedation. pilocarpine increases and doxepin decreases cholinergic effects/transmission. May lower seizure threshold; keep bupropion dose as low as possible. Monitor Closely (2)doxepin increases effects of epinephrine by unknown mechanism. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Effect of interaction is not clear, use caution. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Either increases effects of the other by pharmacodynamic synergism. Risk of arrhythmias or hypotension. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. Weight gain can be short or long term. fluphenazine and doxepin both increase QTc interval. procarbazine and doxepin both increase serotonin levels. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.cenobamate, doxepin. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)pilocarpine increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown. If not feasible, avoid use of abametapir. both increase serotonin levels; increased risk of serotonin syndrome. doxepin and trimipramine both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. tramadol and doxepin both increase sedation. Monitor Closely (1)doxepin and telavancin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Effect of interaction is not clear, use caution. Either increases toxicity of the other by serotonin levels. If you are a Mayo Clinic patient, this could Use Caution/Monitor. Modify Therapy/Monitor Closely. doxepin increases and dextroamphetamine decreases sedation. Avoid or Use Alternate Drug.clomipramine and doxepin both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. Revisions to product labeling. Use Caution/Monitor. Clinical depression: What does that mean? Modify Therapy/Monitor Closely. Use Caution/Monitor. Other (see comment). doxepin increases and norepinephrine decreases sedation. Use Caution/Monitor. cisatracurium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, metaproterenol. Use Caution/Monitor. quetiapine and doxepin both increase sedation. Use Caution/Monitor. However, cyclic antidepressants may be a good option for some people. Use Caution/Monitor. privacy practices. doxepin and protriptyline both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin increases and caffeine decreases sedation. Either increases effects of the other by serotonin levels. Use Caution/Monitor. The usual dosage range is 75 to 150 mg per day. Avoid or Use Alternate Drug. doxepin increases levels of glycopyrrolate by unknown mechanism. amoxapine and doxepin both increase serotonin levels. official website and that any information you provide is encrypted Use Caution/Monitor. tramadol and doxepin both increase sedation. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Amoxapine (prescribing information). Monitor Closely (1)oxycodone and doxepin both increase sedation. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. doxepin and dolasetron both increase QTc interval. celecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. Use Caution/Monitor. Monitor Closely (1)flurazepam and doxepin both increase sedation. This activity will highlight the mechanism of action . Additive impairment of motor skills. Monitor Closely (1)doxepin and paroxetine both increase QTc interval. restrictions. Minor (1)doxepin increases effects of insulin lispro by pharmacodynamic synergism. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)peginterferon alfa 2b, doxepin. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor.doxepin and albuterol both increase QTc interval. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. This website also contains material copyrighted by 3rd parties. Contraindicated (1)thioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and pasireotide both increase QTc interval. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Either increases toxicity of the other by serotonin levels. Exact mechanism for doxepin's sleep maintenance effect is unknown; however, doxepin's action is believed to result from antagonism of the histamine H1 receptor, Mechanism of action for depression is unknown; may increase CNS synaptic concentrations of serotonin and norepinephrine by inhibiting reuptake. Avoid or Use Alternate Drug. Monitor Closely (2)quetiapine and doxepin both increase sedation. and can have potentially adverse consequences. promethazine and doxepin both increase QTc interval. However, interactions are not common. Modify Therapy/Monitor Closely. Moderately clinically significant. Monitor Closely (1)osilodrostat and doxepin both increase QTc interval. Avoid or Use Alternate Drug. doxepin and buprenorphine both increase QTc interval. triclofos and doxepin both increase sedation. Limit dosages and durations to the minimum required. difelikefalin and doxepin both increase sedation. estrogens conjugated synthetic, doxepin. Use Caution/Monitor. ECG monitoring is recommended if coadministered. Use Caution/Monitor. http://www.wolterskluwercdi.com/facts-comparisons-online/. Use Caution/Monitor. Increased antidepressant serum concentrations may occur. Monitor Closely (1)clorazepate and doxepin both increase sedation. Canada residents can call a provincial poison control center. Use Caution/Monitor.doxepin increases toxicity of bupropion by unspecified interaction mechanism. It can help prevent suicidal thoughts/attempts and provide other important benefits. doxepin increases effects of acarbose by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)dichlorphenamide and doxepin both decrease serum potassium. Minor/Significance Unknown. Monitor Closely (1)doxepin and scullcap both increase sedation. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Other (see comment). Minor/Significance Unknown. Avoid or Use Alternate Drug. mitotane decreases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Effect of interaction is not clear, use caution. Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Serious - Use Alternative (1)doxepin and macimorelin both increase QTc interval. Accessed Aug. 13, 2019. Monitor Closely (1)celecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor.

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